Pluronic F 127 Prill, also known as Poloxamer 407, is a non-ionic difunctional block copolymer surfactant belonging to the family of copolymers called Pluronics. It is is 100% active and relatively nontoxic. It is composed of hydrophilic polyethylene oxide (PEO) chains and hydrophobic polypropylene oxide (PPO) chains arranged in a triblock structure. Pluronic F 127 Prill is commercially available in various forms, with the prill form referring to solid, spherical particles.
As a non-ionic surfactant, Pluronic F 127 Prill exhibits amphiphilic properties, meaning it possesses both hydrophilic (water-attracting) and hydrophobic (water-repelling) regions. This unique structure allows it to function as a surfactant, emulsifier, solubilizer, and stabilizer in a wide range of applications.
Uses of Pluronic F 127 Prill include:
- Pharmaceutical applications: Pluronic F 127 Prill is commonly used in pharmaceutical formulations as a solubilizing agent, stabilizer, and emulsifier. It can improve the solubility of poorly soluble drugs, enhance drug delivery, and stabilize protein and peptide formulations.
- Controlled drug delivery systems: Pluronic F 127 Prill is utilized in the formulation of controlled-release drug delivery systems such as hydrogels, nanoparticles, and micelles. Its ability to form thermoreversible gels at physiological temperatures allows for sustained drug release and targeted delivery.
- Tissue engineering and regenerative medicine: Pluronic F 127 Prill is employed in tissue engineering scaffolds and regenerative medicine applications due to its biocompatibility and ability to form hydrogels. It can provide structural support, promote cell adhesion, and facilitate the controlled release of bioactive molecules.
- Cosmetics and personal care products: Pluronic F 127 Prill is incorporated into cosmetic formulations such as creams, lotions, and gels as an emulsifier, stabilizer, and viscosity modifier. It helps to improve product consistency, texture, and stability.
- Industrial applications: Pluronic F 127 Prill finds use in various industrial applications, including lubricants, coatings, and detergents. It can act as a dispersing agent, wetting agent, and foam stabilizer in these formulations.
Overall, Pluronic F 127 Prill is a versatile non-ionic surfactant with diverse applications across pharmaceuticals, drug delivery, tissue engineering, cosmetics, and industrial sectors. Its amphiphilic nature, biocompatibility, and ability to form thermoreversible gels make it an invaluable component in various formulations and applications.
The chemical structure of Pluronic® F127 Prill terminates in primary hydroxyl groups:
